| Autor: |
B, Ojo, L A, Findsen, N, Igarashi, B, Kong, B K, Chowdhury |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Drug design and discovery. 14(1) |
| ISSN: |
1055-9612 |
| Popis: |
As part of a continuing effort aimed at the development of efficacious antihistaminic and bronchodilator agents for the treatment of asthma and related respiratory diseases, a series of novel trisubstituted deoxyvasicine derivatives was designed and synthesized. Bronchodilatory activity of pure samples of ligands 17a-d, and DL-8-chlorovasicine hydrochloride is investigated and compared with isoprenaline and aminophylline. These studies confirm the activity of ligands 17a-d and the potentiating effect of 17c on aminophylline. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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