High-yielding
| Autor: | Rhiannon, Beard, Nisha, Singh, Christophe, Grundschober, Antony D, Gee, Edward W, Tate |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Fluorine Radioisotopes Brain Olfactory Bulb Peptides Cyclic Heterocyclic Compounds 1-Ring Structure-Activity Relationship Chemistry Receptors Oxytocin Positron-Emission Tomography Animals Female Radiopharmaceuticals Rats Wistar hormones hormone substitutes and hormone antagonists Administration Intranasal Half-Life |
| Zdroj: | Chemical Communications (Cambridge, England) |
| ISSN: | 1364-548X |
| Popis: | Probing the mechanism of intranasal oxytocin brain uptake through generation and validation of a novel peptide PET tracer. A novel Al18F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake following intranasal administration, a common yet controversial delivery route for oxytocin-based therapeutics. |
| Databáze: | OpenAIRE |
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