| Autor: |
Adam K, Klein, Michael A, Brito, Sayeh, Akhavan, Dylan R, Flanagan, Nikki, Le, Tatum, Ohana, Anand S, Patil, Erin M, Purvis, Carl, Provenzano, Alex, Wei, Lucy, Zhou, Aaron, Ettenberg |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Psychopharmacology. 234(3) |
| ISSN: |
1432-2072 |
| Popis: |
Cocaine produces significant aversive/anxiogenic actions whose underlying neurobiology remains unclear. A possible substrate contributing to these actions is the serotonergic (5-HT) pathway projecting from the dorsal raphé (DRN) to regions of the extended amygdala, including the bed nucleus of the stria terminalis (BNST) which have been implicated in the production of anxiogenic states.The present study examined the contribution of 5-HT signaling within the BNST to the anxiogenic effects of cocaine as measured in a runway model of drug self-administration.Male Sprague-Dawley rats were fitted with bilateral infusion cannula aimed at the BNST and then trained to traverse a straight alley once a day for a single 1 mg/kg i.v. cocaine infusion delivered upon goal-box entry on each of 16 consecutive days/trials. Intracranial infusions of CP 94,253 (0, 0.25, 0.5, or 1.0 μg/side) were administered to inhibit local 5-HT release via activation of 5-HTIntra-BNST infusions of the 5-HTInhibition of 5-HT |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full text from SpringerLink