| Autor: |
B, Desoize, P, Dumont, L, Manot, S, Urien, R, Dufour, G, Berthiot |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Anticancer research. 14(6A) |
| ISSN: |
0250-7005 |
| Popis: |
Cisplatin toxicity could be decreased by adjusting its dosage to each patient. For this purpose, a limited sampling method was established and validated based on a Bayesian approach taken using the values of assays during a 5-day continuous infusion of cisplatin. Using this method, a dosing model to achieve a target plasma concentration of total platinum (Pt) was evaluated retrospectively; the calculated dose of cisplatin was 95.0 to 104.8% of the actual dose. This model was then studied prospectively and the actual plasma Pt concentration reached at the end of the infusion was 94.9% of the target concentration. A strong correlation was observed between the clearance of Pt and the calculated clearance of creatinine or Cockroft index (p = 1.7 x 10(-11), and this correlation was used to develop another cisplatin dosing model. With this model the actual concentration reached at the end of the infusion was 85.3% of the theoretical concentration. The Bayesian approach gave reliable results for most clinical uses, whereas the creatinine based model has to be improved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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