Serum cytokine profile of pregnant women with malaria, intestinal helminths and HIV infections in Ibadan, Nigeria
| Autor: | Olawunmi R, Rabiu, Hannah, Dada-Adegbola, Catherine O, Falade, Olatunbosun G, Arinola, Alexander B, Odaibo, Olusegun G, Ademowo |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Plasmodium Interleukin-13 Adolescent Coinfection Tumor Necrosis Factor-alpha Interleukin-17 Helminthiasis Nigeria HIV Infections Middle Aged Interleukin-10 Malaria Young Adult Pregnancy Helminths Prevalence Animals Cytokines Humans Female Interleukin-4 Pregnant Women Intestinal Diseases Parasitic |
| Zdroj: | Parasitology research. 121(7) |
| ISSN: | 1432-1955 |
| Popis: | Malaria, helminthiasis and HIV are widespread in developing countries taking a heavy toll on pregnant women. Due to similar environmental and human factors of transmission, they co-exist. The epidemiology and pathology of these diseases have been extensively studied but data on serum cytokine profile changes which is crucial in pregnancy is limited. The aim of this study was to evaluate the co-infections and their impact on peripheral blood cytokines. Blood and stool samples were collected from recruited 18-45-year-old pregnant women in different trimesters who were apparently healthy with no obvious complications in pregnancy. Pretested questionnaires were administered for personal and socio-demographic details. Malaria parasitemia in Giemsa-stained thick blood films was examined microscopically. Stool samples were screened for helminths using Kato-Katz method. Cytokine levels of TNF-α, IFN-γ, IL-1α, IL-2, IL-4, IL-6, IL-10, IL-12p70, IL-13 and IL-17 in 121 serum samples were determined using ELISA. Data were analysed using descriptive statistics and Mann-Whitney U test at α |
| Databáze: | OpenAIRE |
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