A toxic shock syndrome toxin mutant of Staphylococcus aureus isolated by allelic replacement lacks virulence in a rabbit uterine model

Autor:	R, Sloane, J C, de Azavedo, J P, Arbuthnott, P J, Hartigan, B, Kreiswirth, R, Novick, T J, Foster
Rok vydání:	1991
Předmět:	Staphylococcus aureus Superantigens Virulence Bacterial Toxins Immunoblotting Restriction Mapping Uterus Shock Septic Enterotoxins Mutation Mutagenesis Site-Directed Animals Female Rabbits Cloning Molecular Alleles
Zdroj:	FEMS microbiology letters. 62(2-3)
ISSN:	0378-1097
Popis:	The gene coding for toxic shock syndrome toxin-1 in S. aureus was inactivated by allelic replacement in two TSS-associated strains. One mutant derived from FRI1169 (a non-enterotoxigenic strain) lacked virulence in the rabbit uterine chamber infection model. This suggests that TSST-1 is the only determinant produced by this strain that can induce the symptoms of shock in rabbits. A novel method for allelic replacement involving transduction of plasmid integrants is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::93c4de9a299894645263939b7a25fdef https://pubmed.ncbi.nlm.nih.gov/2040432 Zobrazit plný text záznamu Plný text