| Autor: |
Nathalie K, Zgheib, Habib, El-Khoury, Dimitri, Maamari, Maya, Basbous, Raya, Saab, Samar A, Muwakkit |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Personalized medicine. 18(5) |
| ISSN: |
1744-828X |
| Popis: |
Lay abstract This study aimed at uncovering variants in the genetic material of Arab children, that might predispose them to develop a specific treatment-related adverse effect, during their therapy for acute lymphoblastic leukemia (a type of blood cancer). We looked at specific changes in the DNA of our patient cohort that might predispose them to develop treatment-induced osteonecrosis. Osteonecrosis is by definition a loss of blood flow to the bone tissue in one's body, causing the bone to die. Osteonecrosis may be caused by long-term exposure to steroid-based medication, among which dexamethasone. Dexamethasone a main component of the combination of chemotherapeutic agents used to treat acute lymphoblastic leukemia. Our findings suggested that children who had one of the variants detected in a specific location of DNA, the |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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