| Autor: |
L V, Chesnokova, I M, Petrov, I A, Troshina, I V, Medvedeva |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Klinicheskaia meditsina. 91(12) |
| ISSN: |
0023-2149 |
| Popis: |
To study levels of systemic inflammation markers and plasminogen activator inhibitor-1 (PAL-1) in patients with metabolic syndrome (MS) and establish their relationship with the progress of selected stages of non-alcoholic fatty liver disease (NAFLD).129 patients aged 18-59 yr with abdominal obesity and MS underwent elastometry for the assessment of the degree of fibrosis depending on concomitant metabolic disorders and measurement of proinflammatory cytokine levels.Disorders of carbohydrate metabolism in MS patients are associated with the high levels of systemic inflammation markers (CRP, TNF-α, IL-6) and a two-fold rise in the PAI-1 level. The progress of fibrosis is associated with the increase of cytokine levels.Patients with MS and NAFLD associated with disorders of carbohydrate metabolism need to be examined by elastometry for the detection of fibrosis with simultaneous measurement of IL-6 and PAI-1 levels as cardiovascular risk factors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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