[Modulation of the antiarrhythmic effect by endogenous opioids during adaptation to hypoxia in rats]

Autor:	Iu B, Lishmanov, E V, Uskina, A V, Krylatov, B Iu, Kondrat'ev, D S, Ugdyzhekova, L N, Maslov
Rok vydání:	1998
Předmět:	Enkephalin Methionine Narcotic Antagonists Receptors Opioid kappa Hypothalamus Receptors Opioid mu Arrhythmias Cardiac Ligands Adaptation Physiological Rats Receptors Opioid delta Receptors Opioid Animals Rats Wistar Hypoxia
Zdroj:	Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 84(4)
ISSN:	0869-8139
Popis:	Adaptation of rats to hypoxia increased the heart resistance against arrhythmogenic effects. The Met-enkephaline-Arg6-Phe7 contant increased in the hypothalamus of the adapted animals. The blockers of mu- and delta-opioid receptors reduced the antiarrhythmic effect of the adaptation, whereas chi-receptor inhibitor, nor-binaltorphimine, completely abolished it. The findings suggest the antiarrhythmic effect depends on an increase of the endogenous opioids level and modulated effect of these peptides upon autonomous nervous system.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9399314724e4b913e1a48ebb0dc2b94d https://pubmed.ncbi.nlm.nih.gov/9742615 Zobrazit plný text záznamu