| Autor: |
H, Vihervuori, T A, Autere, H, Repo, S, Kurki, L, Kallio, M M, Lintunen, K, Talvinen, P, Kronqvist |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of Cancer Research and Clinical Oncology |
| ISSN: |
1432-1335 |
| Popis: |
Purpose Tumor inflammatory response was evaluated as a prognostic feature in triple-negative breast cancer (TNBC) and compared with the clinical prognosticators of breast cancer and selected biomarkers of cancer cell proliferation. Methods TNBC patients (n = 179) with complete clinical data and up to 18-year follow-up were obtained from Auria biobank, Turku University Hospital, Turku, Finland. Tumor-infiltrating lymphocytes (TILs) and several subtypes of inflammatory cells detected with immunohistochemistry were evaluated in different tumor compartments in full tissue sections and tissue microarrays. Results Deficiency of stromal TILs and low number of CD8+ T cells independently predicted mortality in TNBC (HR 2.4, p 0.02 and HR 2.1, p 0.02, respectively). Each 10% decrease in stromal TILs resulted in 20% increased risk of mortality. An average of 13.2-year survival difference was observed between the majority (> 75%) of patients with low ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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