Establishment and characterization of a CD5 positive, immunosuppressive human myeloma cell line

Autor:	R J, Scibienski, T G, Paglieroni, M R, MacKenzie
Rok vydání:	1990
Předmět:	Antigens Differentiation B-Lymphocyte B-Lymphocytes Antigens CD Karyotyping Immune Tolerance Tumor Cells Cultured Humans Immunoglobulins CD5 Antigens Multiple Myeloma Antigens Differentiation Glycoproteins Neoplasm Proteins
Zdroj:	Leukemia. 4(11)
ISSN:	0887-6924
Popis:	A continuously growing, in vitro cell line with plasma cell characteristics has been established from the bone marrow of a patient with multiple myeloma. Surface marker characterization of the cells revealed a combination of markers normally associated with different developmental stages in the B cell lineage. The cell secretes immunoglobulin at a relatively low rate. The cell also expresses CD5 and secretes a factor which suppresses in vitro mitogen and antigen induced immunoglobulin synthesis by normal PBL.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::934b69746367119eb8d409ba664020e8 https://pubmed.ncbi.nlm.nih.gov/1700238 Zobrazit plný text záznamu