| Autor: |
Luděk, Rožnovský, Irena, Orságová, Lenka, Petroušová, Josef, Tvrdík, Libuše, Kabieszová, Martin, Rydlo, Ivo, Lochman, Alena, Kloudová |
| Jazyk: |
čeština |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Klinicka mikrobiologie a infekcni lekarstvi. 16(5) |
| ISSN: |
1211-264X |
| Popis: |
Hepatitis B vaccination was started in 41 patients with end-stage liver disease who were liver transplant candidates. Patients received three 20 microg or, starting from 1999, 40 microg doses of recombinant vaccine at 0, 2 and 4 weeks. Blood samples were obtained 4 weeks after vaccination or each revaccination; patients without protective hepatitis B surface antibodies (anti-HBs) were once or repeatedly revaccinated. Thirty-eight patients received at least 3 doses of vaccine. Protective anti-HBs level (≥ 10 IU/l) was detected in 17 of 34 patients (50 %) after the third up to eight dose. No case of chronic HBsAg carrier status was detected. Immunisation against hepatitis B in persons with liver cirrhosis is associated with a poor response and new vaccines should be considered for these patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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