Advances in genome editing through control of DNA repair pathways

Autor:	Charles D, Yeh, Christopher D, Richardson, Jacob E, Corn
Rok vydání:	2018
Předmět:	Gene Editing Eukaryotic Cells DNA Repair Animals Humans DNA Damage
Zdroj:	Nature cell biology. 21(12)
ISSN:	1476-4679
Popis:	Eukaryotic cells deploy overlapping repair pathways to resolve DNA damage. Advancements in genome editing take advantage of these pathways to produce permanent genetic changes. Despite recent improvements, genome editing can produce diverse outcomes that can introduce risks in clinical applications. Although homology-directed repair is attractive for its ability to encode precise edits, it is particularly difficult in human cells. Here we discuss the DNA repair pathways that underlie genome editing and strategies to favour various outcomes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9311b218b669127017a4644305ba07cc https://pubmed.ncbi.nlm.nih.gov/31792376 Zobrazit plný text záznamu Full text from SpringerLink