| Autor: |
D J, Byerley, T E, Kiser, J K, Bertrand, R R, Kraeling |
| Rok vydání: |
1992 |
| Předmět: |
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| Zdroj: |
Journal of animal science. 70(9) |
| ISSN: |
0021-8812 |
| Popis: |
This study was conducted to investigate regulation of LH release by opioid peptides during puberal development in beef heifers. Fourteen heifers were randomly assigned to receive naloxone (opioid antagonist) i.v. at dosages of either 1 mg.kg BW-1.wk-1 (Dose 1) or .25 mg.kg BW-1.wk-1 (Dose 2) for 13 wk or until puberty. Blood was sampled (one sample every 15 min) 6 h before (prenaloxone) and 2 h after naloxone administration. Two hours after naloxone administration, GnRH (10 ng/kg BW) was administered and blood was sampled for 1 h. Nine heifers attained puberty during the study. There were no differences between naloxone dosage groups for any measured variables. Therefore, heifers were grouped dependent on the attainment of puberty. Prenaloxone concentrations of serum LH and LH pulse frequency were normal for prepuberal heifers. Serum LH concentrations increased within 30 min after naloxone 135 of 139 times it was administered (P less than .05). Serum LH concentrations during the hour after naloxone were higher (P less than .05) than those during the hour before naloxone in both puberal and nonpuberal heifers. In puberal heifers, serum LH pulse height during the hour after naloxone was greater (P less than .02) at 5 wk before puberty and lower (P less than .02) the week before puberty than at other times during the trial. There was no effect of week on serum LH pulse height after naloxone in heifers that failed to attain puberty during the study. Response of LH to GnRH was similar between groups.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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