| Popis: |
The skeleton is not a single entity; the age of onset, rate of accrual and age of attainment of peak bone density vary according to gender and according to region. Exposure of life style factors during growth and disease may produce site specific deficits in bone density in adulthood. Since bone mass in the elderly depends beside the rate of involutional bone loss mainly on the peak bone mass its optimal development in childhood and adolescence appears as being the key issue problem in prophylactic strategy of osteoporotic therapy. |
