In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1

Autor:	Daniel J, Rubins, Xiangjun, Meng, Paul, McQuade, Michael, Klimas, Krista, Getty, Shu-An, Lin, Brett M, Connolly, Stacey S, O'Malley, Hyking, Haley, Mona, Purcell, Liza, Gantert, Marie, Holahan, Joel, Lindgren, Pär, Eklund, Caroline, Ekblad, Fredrik Y, Frejd, Eric D, Hostetler, Dinko E, González Trotter, Jeffrey L, Evelhoch
Rok vydání:	2020
Předmět:	Fluorine Radioisotopes Antibodies Monoclonal Gallium Radioisotopes Macaca mulatta Xenograft Model Antitumor Assays B7-H1 Antigen Molecular Imaging Mice Cell Line Tumor Neoplasms Positron-Emission Tomography Animals Humans Tissue Distribution Immunotherapy Radiopharmaceuticals Radiometry
Zdroj:	Molecular imaging and biology. 23(2)
ISSN:	1860-2002
Popis:	In vivo imaging of programmed death ligand 1 (PD-L1) during immunotherapy could potentially monitor changing PD-L1 expression and PD-L1 expression heterogeneity within and across tumors. Some protein constructs can be used for same-day positron emission tomography (PET) imaging. Previously, we evaluated the PD-L1-targeting Affibody molecule [ZEx vivo biodistribution measurements showed that both tracers had25 fold higher accumulation in LOX tumors than SUDHL6 ([[
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::92e9c29eb62cb12b8b8bb175e9390d4f https://pubmed.ncbi.nlm.nih.gov/33098025 Zobrazit plný text záznamu Full text from SpringerLink