| Autor: |
V, Del Gobbo, M G, Giganti, R, Zenobi, V, Villani, M G, Premrov |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
American journal of reproductive immunology (New York, N.Y. : 1989). 44(4) |
| ISSN: |
1046-7408 |
| Popis: |
The present study examines the hypothesis that the elevated levels of transforming growth factor (TGF)-beta1 and interleukin (IL)-10 would be protective for the fetus survival during pregnancy-induced hypertension (PIH). Moreover, we evaluate the IL-12 and IL-15 serum concentrations and their relationships with PIH.Serum samples were obtained before the onset of labor from control and PIH groups. Cytokine concentrations were determined by Enzyme-Linked Immunoadsorbent Assay.Our data show that PIH women have significantly higher TGF-beta1 and IL-10 concentrations with respect to control groups (P = 0.0001). Similarly, macrophages from the PIH placentas produce in vitro more elevated TGF-beta1 and IL-10 levels compared to normal pregnant ones (P = 0.02), also in the absence of LPS stimulation. IL-12 and IL-15 serum concentrations were not detectable in all pregnant groups.We have found that PIH women have elevated concentrations of anti-inflammatory/immunosuppressive cytokines, suggesting their important role in fetal allograft protection during the normal and pathological pregnancy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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