| Autor: |
Marius, Müller, Vladimir, Shalgunov, Lars, Hvass, Jesper T, Jørgensen, Vasko, Kramer, Markus, Staudt, Umberto Maria, Battisti, Andreas, Kjaer, Matthias M, Herth |
| Rok vydání: |
2022 |
| Zdroj: |
Bioorganicmedicinal chemistry letters. 80 |
| ISSN: |
1464-3405 |
| Popis: |
Tucatinib is a selective human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitor approved by the U.S. Food and Drug Administration (FDA) in April 2020 for HER2-positive lesions in metastatic breast cancer patients, including CNS metastases. In this article, we attempted to develop the first small molecule, blood-brain-barrier (BBB) penetrant HER2 PET imaging probe based on tucatinib. [ |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect