| Autor: |
Renliang, Yu, Fan, Wang, Jie, Yin, Yugen, Shi, Yu, Wang, Shengnan, Wen, Hesheng, Hu, Suhua, Yan |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
International journal of clinical and experimental pathology. 11(2) |
| ISSN: |
1936-2625 |
| Popis: |
Background: Myocardial infarction (MI) accompanied with abnormal sympathetic innervation, meanwhile, some studies have revealed the oxytocin (OT) and its receptor (OTR) have a relationship with MI and sympathetic system. It is assumed that OT has an close relationship with superior cervical ganglion (SCG), but the existence of oxytocin receptors in SCG has not been well clarified. Objective: Our research aims to explore the expression of OTR in SCG in the setting of MI. Methods and results: MI was induced by coronary artery ligation. Rats were randomly assigned to 2 groups: control, MI. The expression of OTR was measured by Western blotting. Distribution of OTR in SCG was investigated by immunofluorescence. Retrograde tracing test revealed the sprouting of tyrosine hydroxylase (TH: the markers of sensory afferent fibers) from cardiac to SCG neurons. The double-immunofluorescence evidence showed that OTR was co-localized and concomitantly changed with TH and the retrograde neuronal labeling from the cardiac afferent nerves. By Western blotting, the protein of OTR in the MI group was higher than those of the control group. Conclusions: The expression of OTR in SCG after experimental myocardial infarction group was enhanced, suggesting the involvement of OTR in SCG may play a role in the transmission of sympathetic responses after MI. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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