| Autor: |
Jaakko, Pehkonen, Jutta, Viinikainen, Jaana T, Kari, Petri, Böckerman, Terho, Lehtimäki, Jorma, Viikari, Olli, Raitakari |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Preventive medicine. 154 |
| ISSN: |
1096-0260 |
| Popis: |
This study quantifies the causal effect of birth weight on cardiovascular biomarkers in adulthood using the Cardiovascular Risk in Young Finns Study (YFS). We apply a multivariable Mendelian randomization (MVMR) method that provides a novel approach to improve inference in causal analysis based on a mediation framework. The results show that birth weight is linked to triglyceride levels (β = -0.294; 95% CI [-0.591, 0.003]) but not to low-density lipoprotein (LDL) cholesterol levels (β = 0.007; 95% CI [-0.168, 0.183]). The total effect of birth weight on triglyceride levels is partly offset by a mediation pathway linking birth weight to adult BMI (β = 0.111; 95% CI [-0.013, 0.234]). The negative total effect is consistent with the fetal programming hypothesis. The positive indirect effect via adult BMI highlights the persistence of body weight throughout a person's life and the adverse effects of high BMI on health. The results are consistent with previous findings that both low birth weight and weight gain increase health risks in adulthood. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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