| Autor: |
Jun, Wang, Jie, Liang, Jin, Yao, Hai Xin, Song, Xiao Tian, Yang, Fang Chao, Wu, Ye, Ye, Jian Hua, Li, Tao, Wu |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Aging clinical and experimental research. 34(4) |
| ISSN: |
1720-8319 |
| Popis: |
Hypertonic dextrose prolotherapy (HDP) is an injection of a concentrated dextrose solution for the purpose of local treatment of musculoskeletal pain and possible enhancement of repair mechanisms. This systematic review and meta-analysis examines the clinical utility of HDP injection for treatment of knee osteoarthritis (OA). Randomized controlled trials (RCTs) utilizing HDP to treat knee OA were retrieved from MEDLINE, EMBASE, and Cochrane Library (CENTRAL). Identification and inclusion of RCTs utilizing intra-articular and extra-articular administration of HDP vs administration of other injectate or physical therapy as control for knee OA were included. Primary clinical outcomes were changes in knee WOMAC, pain and function score. Secondary outcomes were adverse events related to HDP. For continuous outcomes with same or different measurements, we calculated, respectively the weighted mean difference (WMD) or the standardized mean difference (SMD), respectively. Results were pooled using DerSimonian and Laird random effect models across the included studies and heterogeneity between studies was estimated using the I |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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