[The effect of 1,4-benzodiazepine derivatives on 35S-tert-butylbicyclophosphorothionate binding in the brain of inbred mice with differing emotional stress reactions]

Autor:	Iu A, Blednov, I V, Kosach, S B, Seredenin
Rok vydání:	1997
Předmět:	Brain Chemistry Male Benzodiazepinones Mice Inbred BALB C Alprazolam Dose-Response Relationship Drug Brain Bridged Bicyclo Compounds Heterocyclic Ligands Sulfur Radioisotopes Mice Inbred C57BL Benzodiazepines Mice Anti-Anxiety Agents Species Specificity Animals Stress Psychological
Zdroj:	Eksperimental'naia i klinicheskaia farmakologiia. 60(4)
ISSN:	0869-2092
Popis:	The effect of alprazolam, cinazepam, and hydazepam on the binding of 35S-tert-butylbicyclophosphorothionate with the brain membranes of inbred Balb/c and C57B1/6 mice with a different type of emotional-stress reaction was studied. The displacement curve of 35S-TBPS bound with alprazolam and cinazepam was two-phase in character with different degree of inhibition in the nanomolar and micromolar areas. Hydazepam displaced the bound radioligand only in micromolar concentrations. Displacement of the bound radioligand in the brain membranes began with lower concentrations of the used benzodiazepins in Balb/c animals than in C57B1/6 animals. The emotional-stress effect led to shift of the displacement curves of the bound 35S-TBPS in the direction of higher acting concentrations of the benzodiazepins in the brain membranes of mice of both lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9275e74d8c151a5f9f57f5668ca0196f https://pubmed.ncbi.nlm.nih.gov/9376753 Zobrazit plný text záznamu