A single amino acid residue controls acyltransferase activity in a polyketide synthase from
| Autor: | Hannah K, D'Ambrosio, Jack G, Ganley, Aaron M, Keeler, Emily R, Derbyshire |
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| Rok vydání: | 2021 |
| Zdroj: | iScience. 25(6) |
| ISSN: | 2589-0042 |
| Popis: | Type I polyketide synthases (PKSs) are multidomain, multimodule enzymes capable of producing complex polyketide metabolites. These modules contain an acyltransferase (AT) domain, which selects acyl-CoA substrates to be incorporated into the metabolite scaffold. Herein, we reveal the sequences of three AT domains from a polyketide synthase ( |
| Databáze: | OpenAIRE |
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