Study of siRNA Delivery via Polymeric Nanoparticles in Combination with Angiogenesis Inhibitor for The Treatment of

Autor: Kittiporn, Punuch, Chamaiphorn, Wongwan, Saranrat, Jantana, Chayapol, Somboonyosdech, Kamonlatth, Rodponthukwaji, Natsuda, Kunwong, Kytai T, Nguyen, Vorapan, Sirivatanauksorn, Yongyut, Sirivatanauksorn, Chatchawan, Srisawat, Primana, Punnakitikashem
Rok vydání: 2022
Předmět:
Zdroj: International journal of molecular sciences. 23(20)
ISSN: 1422-0067
Popis: Angiogenesis inhibitor drugs have been explored as important pharmacological agents for cancer therapy, including hepatocellular carcinoma. These agents have several drawbacks, such as drug resistance, nonspecific toxicity, and systemic side effects. Therefore, combination therapy of the drug and small interfering RNA could be a promising option to achieve high therapeutic efficacy while allowing a lower systemic dose. Therefore, we studied adding an alpha-fetoprotein siRNA (
Databáze: OpenAIRE