| Autor: |
M, Usategui-Gomez, S B, Stearns, H W, Toolan |
| Rok vydání: |
1969 |
| Předmět: |
|
| Zdroj: |
American journal of obstetrics and gynecology. 105(8) |
| ISSN: |
0002-9378 |
| Popis: |
Report of a study of Rh antibody titers in the amniotic fluids from 42 Rh-negative sensitized pregnancies is presented. Amniocentesis was performed in the pregnant Rh-negative women having serum Rh antibody titers (indirect Coombs) ranging from 1/64 to 1/4,096. Spectrophotometric analysis was done on the antiRh-D titers. In order to predict the outcome of pregnancy based on the amniotic fluid Rh antibody content, all fetuses were divided into 3 categories. Those with titers of 1/4 or below should correspond to Category I; unaffected or mildly affected babies; those with titers of 1/8 to 1/16 should be in Category II or have moderate to severe disease; while fetuses with titers of 1/32 or above would be in Category III indicating very severe disease. Out of 18 cases with titers of 1/4 or below, 17 were unaffected or mildly affected. In 10 patients titers of 1/8 or 1/16 were observed as the highest titer. 8 infants in this group were moderately to severely affected. 14 cases were observed with titers of 1/32 or above and in 11 of them, the pregnancy outcome was a severely ill or dead infant. The other 3 cases in this group were babies with severe anemia who required 2 or 3 exchange transfusions. It was learned that the antibody titer of amniotic fluid of Rh-sensitized pregnancies can be used as a reliable index of the severity of hemolytic disease in the fetus. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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