Melanocortin 2, 3 and 4 Receptor Gene Expressions are Downregulated in CD8

Autor:	M, Andersen, I, Nagaev, M K, Meyer, O, Nagaeva, J, Wikberg, L, Mincheva-Nilsson, G N, Andersen
Rok vydání:	2017
Předmět:	Adult Male B-Lymphocytes Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha Injections Subcutaneous Receptors Melanocortin Antigens CD19 Adalimumab Down-Regulation Gene Expression CD8-Positive T-Lymphocytes Middle Aged Arthritis Rheumatoid Interferon-gamma Treatment Outcome Antirheumatic Agents Humans Receptor Melanocortin Type 4 Female Lymphocytes Receptor Melanocortin Type 2 Receptor Melanocortin Type 3 T-Lymphocytes Cytotoxic
Zdroj:	Scandinavian journal of immunology. 86(1)
ISSN:	1365-3083
Popis:	Melanocortin signalling in leucocyte subsets elicits anti-inflammatory and immune tolerance inducing effects in animal experimental inflammation. In man, however, the effects of melanocortin signalling in inflammatory conditions have scarcely been examined. We explored the differential reactions of melanocortin 1-5 receptors (MC1-5R) gene expressions in pathogenetic leucocyte subsets in rheumatoid arthritis (RA) to treatment with TNF-α inhibitor adalimumab. Seven patients with active RA donated blood at start and at 3-month treatment. CD4
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::923e3d563a51daa5a04a19fd9fc4f124 https://pubmed.ncbi.nlm.nih.gov/28426141 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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