How Microbiota-Derived Metabolites Link the Gut to the Brain during Neuroinflammation

Autor:	Jessica, Rebeaud, Benjamin, Peter, Caroline, Pot
Rok vydání:	2022
Předmět:	Mice Multiple Sclerosis Microbiota Neuroinflammatory Diseases Animals Brain Gastrointestinal Microbiome
Zdroj:	International journal of molecular sciences. 23(17)
ISSN:	1422-0067
Popis:	Microbiota-derived metabolites are important molecules connecting the gut to the brain. Over the last decade, several studies have highlighted the importance of gut-derived metabolites in the development of multiple sclerosis (MS). Indeed, microbiota-derived metabolites modulate the immune system and affect demyelination. Here, we discuss the current knowledge about microbiota-derived metabolites implications in MS and in different mouse models of neuroinflammation. We focus on the main families of microbial metabolites that play a role during neuroinflammation. A better understanding of the role of those metabolites may lead to new therapeutical avenues to treat neuroinflammatory diseases targeting the gut-brain axis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::922b4657af0ae2b7bff2db0fedc1ced3 https://pubmed.ncbi.nlm.nih.gov/36077526 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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