| Autor: |
A, Martinez-Simon, E, Cacho-Asenjo, B, Hernando, C, Honorato-Cia, L, Naval, A, Panadero, J M, Nuñez-Cordoba |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Revista espanola de anestesiologia y reanimacion. 64(4) |
| ISSN: |
2340-3284 |
| Popis: |
DexdorThe IRB approved this observational study for patients that underwent oral and maxillofacial ambulatory surgery under dexmedetomidine at the University of Navarra Clinic from February 2013 to November 2014. According to the loading dose the patients were grouped into 3 categories:0.5, 0.5, and0.5μg/kg. Optimal level of sedation was defined as bispectral index85. Data were analyzed using survival analysis techniques. Vasoactive drugs requirements was evaluated using exact logistic regression.Eighty-one patients were evaluated. Hazard ratios for patients in 0.5 and0.5μg/kg loading dose categories for achieving a bispectral index85 were 1.5 (95% CI 0.9, 2.6) and 1.8 (95% CI 0.8, 3.9), respectively, compared with the lowest category. Five patients (6.2%) required atropine for bradycardia. Patients in the group0.5μg/kg showed greater risk of requiring atropine compared with the group0.5μg/kg (odds ratio 2.2; 95% CI 0.03, 183).Loading dose of dexmedetomidine0.5μg/kg appears minimize the time to achieve and maintain an optimal level of sedation during the first 60min of procedure. Further investigation to elucidate the association between loading dose of dexmedetomidine and subsequent atropine requirements may be warranted. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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