| Autor: |
Marian, Kacerovsky, Roberto, Romero, Lenka, Pliskova, Radka, Bolehovska, Helena, Hornychova, Adela, Matejkova, Hana, Vosmikova, Ctirad, Andrys, Martina, Kolackova, Piotr, Laudański, Vera, Pelantova, Bo, Jacobsson, Ivana, Musilova |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
J Matern Fetal Neonatal Med |
| ISSN: |
1476-4954 |
| Popis: |
OBJECTIVE: The primary aim of this study was to assess the rate and load of amniotic fluid Chlamydia trachomatis DNA and their association with intra-amniotic infection and intra-uterine inflammatory complications in women with PPROM. The secondary aim was to assess the short-term morbidity of newborns from PPROM pregnancies complicated by amniotic fluid Chlamydia trachomatis DNA. METHODS: A retrospective study of 788 women with singleton pregnancies complicated by PPROM between 24+0 and 36+6 weeks of gestation was performed. Transabdominal amniocenteses were performed at the time of admission. Chlamydia trachomatis DNA in the amniotic fluid was assessed by real-time PCR using a commercial AmpliSens(®) C. trachomatis/Ureaplasma/M. hominis-FRT kit, and the level of Ct DNA was quantified. RESULTS: Amniotic fluid Chlamydia trachomatis DNA complicated 2% (16/788) of the PPROM pregnancies and was present in very low loads (median 57 copies DNA/mL). In addition to amniotic fluid Chlamydia trachomatis DNA, other bacteria were detected in 62% (10/16) of the Chlamydia trachomatis DNA-complicated PPROM pregnancies. Amniotic fluid Chlamydia trachomatis DNA was associated with intra-amniotic infection, histologic chorioamnionitis (HCA), and funisitis in 31%, 47%, and 33%, respectively. The presence of Chlamydia trachomatis DNA accompanied by Ureaplasma species in the amniotic fluid was associated with a higher rate of HCA than the presence of amniotic fluid Chlamydia trachomatis DNA alone. The composite neonatal morbidity in newborns from PPROM pregnancies with amniotic fluid Chlamydia trachomatis DNA was 31%. CONCLUSION: The presence of Chlamydia trachomatis DNA in the amniotic fluid is a relatively rare condition in PPROM. Amniotic fluid Chlamydia trachomatis DNA in PPROM is not related to intensive intra-amniotic and intrauterine inflammatory responses or adverse short-term neonatal outcomes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
