| Autor: |
Xiao-Fang, Wu, Li-Yun, Wang, Jian-Hua, Yi, Jian, Lei, Yu-Hong, Ao, Jian-Jun, Li, Jing, Han |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 38(2) |
| ISSN: |
1673-4254 |
| Popis: |
OBJECTIVE: To investigate the protective effects of paeoniflorin against PM2.5-induced damage in BEAS-2B cells and explore the possible mechanism. METHODS: With a factorial design, this study was performed to observe the protective effects of different doses of paeoniflorin against PM2.5-induced BEAS-2B cell growth inhibition and the effects of paeoniflorin on the contents of malondialdehyde (MDA) and intracellular reactive oxygen species (ROS) in the cell cultures. RESULTS: Exposure to increased PM2.5 concentrations caused significant decrease in the cell survival rate (P < 0.05) with a clear dose-response relationship (r=-0.759, P < 0.05). Treatment of the cells with paeoniflorin significantly attenuated PM2.5-induced inhibition of BEAS-2B cell survival (P < 0.05), but the effect of paeoniflorin was not dose-dependent (P > 0.05). PM2.5 exposure also significantly increased the contents of MDA and intracellular ROS (P < 0.05), and paeoniflorin obviously antagonized these effects of PM2.5. CONCLUSION: Paeoniflorin can protect BEAS-2B cells from PM2.5-induced growth inhibition, and the mechanism might be related to the anti-oxidant effects of paeoniflorin. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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