| Autor: |
S, Micuda, M, Hodac, L, Sispera, P, Parízek, M, Pleskot, G, Zimova, J, Cerman, J, Martínková, V, Pidrman |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Physiological research. 50(2) |
| ISSN: |
0862-8408 |
| Popis: |
The present study was undertaken to evaluate the use of cortisol 6beta-hydroxylation in defining the effect of amiodarone on cytochrome CYP3A activity. To accomplish this goal, the in vivo activity of CYP3A was estimated by measuring the 24-hour urinary excretion of 6beta-hydroxycortisol (6beta-OHC) and by calculating 24-hour ratio of 6beta-hydroxycortisol to urinary free cortisol (6beta-OHC/UFC ratio). Nine cardiac patients scheduled for amiodarone treatment were recruited to participate in this study. Urine was collected over a 24-hour period from each subject before the first amiodarone administration and during the third day of oral administration of amiodarone (200 mg four times daily as a loading dose). Three days of amiodarone treatment caused a significant decrease (p0.05) in both the 6beta-OHC/UFC ratio and the 24-hour urinary excretion of 6beta3-OHC. These results suggest that amiodarone is an inhibitor of CYP3A activity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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