| Autor: |
A M, LeVine, M D, Bruno, K M, Huelsman, G F, Ross, J A, Whitsett, T R, Korfhagen |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Journal of immunology (Baltimore, Md. : 1950). 158(9) |
| ISSN: |
0022-1767 |
| Popis: |
To determine the role of surfactant protein A (SP-A) in host defense, the murine SP-A locus was targeted by homologous recombination to produce mice lacking SP-A. SP-A -/- and control mice were infected with group B streptococcus (GBS) by intratracheal instillation. Pulmonary infiltration 6 and 24 h following infection was more severe in SP-A -/- than in control mice, and was associated with increased numbers of GBS in lung homogenates. Dissemination of GBS to the spleen was observed more frequently in SP-A -/- mice. Pulmonary infiltration with macrophages was similar in both groups; however, the number of bacteria associated with alveolar macrophages was decreased in the SP-A-deficient mice. There was no detectable compensatory increase in surfactant protein D, the other known pulmonary collectin, in response to GBS instillation. SP-A plays an important role in vivo, enhancing clearance of GBS from the lung and inhibiting systemic dissemination of the organism. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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