| Autor: |
Jens, Larsen, Maja, Lambert, Henrik, Pettersson, Thomas, Vifian, Mogens, Larsen, Anna, Ollerstam, Pontus, Hegardt, Cecilia, Eskilsson, Steen, Laursen, Anders, Soehoel, Tine, Skak-Nielsen, Lene M, Hansen, Nina Ø, Knudsen, Stefan, Eirefelt, Morten D, Sørensen, Tatiana G, Stilou, Simon F, Nielsen |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Journal of medicinal chemistry. 63(23) |
| ISSN: |
1520-4804 |
| Popis: |
We describe the design of a novel PDE4 scaffold and the exploration of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-soft) while being stable in human skin. Compound |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
