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The immune-modulating activity of "Ferrovir" medication in system in vitro was analyzed using neoplastic cellular line MT-4 as a model. Ferrovir decreased number of cells containing such markers of activation as CD28+, CD38+, CD62L+, CD69+ and HLA-DR+.Under 24 hours incubation period of cells in presence of 500 mkg per ml of medication, indices of decreasing of number of cells expressing these proteins (IRE), for proteins CD28, CD38, CD62L and HLA-DR made up to 1,9 ± 0,4, 1,3 ± 0,4, 1,2 ± 0,4, 1,1 ± 0,06 correspondingly. At prolonged incubation of cells in presence of Ferovir, the maximal effect was observed after 7 days of incubation and IRE for proteins mentioned above made up to 3,2, 3,4, 6,2, 1,4 и 3,1 correspondingly. Only for protein CD62L was marked a significant decreasing of number of cells bringing this marker and at 11th day of cells cultivation in presence of Ferrovir (IRE 3.89). It is possible that such an action of Ferrovir can decrease the process of spreading of cells containing integrated pathogenic material through organs and tissues of organism and slow down generalization of infectious process. The obtained results indicate that Ferrovir has an immune-modulating activity in vitro since it can decrease activating potential of neoplastic line of cells MT-4. These features can be useful in treatment of various type of cancer, HIV-infection and other human diseases. The decreasing of level of activation of cells of immune system also decreases risk of development of opportunistic infections. |
