| Autor: |
Nicole C, Victoria, Ezequiel, Marron Fernandez de Velasco, Olga, Ostrovskaya, Stefania, Metzger, Zhilian, Xia, Lydia, Kotecki, Michael A, Benneyworth, Anastasia N, Zink, Kirill A, Martemyanov, Kevin, Wickman |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Biological psychiatry. 80(10) |
| ISSN: |
1873-2402 |
| Popis: |
Cognitive dysfunction occurs in many debilitating conditions including Alzheimer's disease, Down syndrome, schizophrenia, and mood disorders. The dorsal hippocampus is a critical locus of cognitive processes linked to spatial and contextual learning. G protein-gated inwardly rectifying potassium ion (GIRK/Kir3) channels, which mediate the postsynaptic inhibitory effect of many neurotransmitters, have been implicated in hippocampal-dependent cognition. Available evidence, however, derives primarily from constitutive gain-of-function models that lack cellular specificity.We used constitutive and neuron-specific gene ablation models targeting an integral subunit of neuronal GIRK channels (GIRK2) to probe the impact of GIRK channels on associative learning and memory.Constitutive Girk2Our data suggest that GIRK channels in dorsal hippocampal pyramidal neurons are necessary for normal learning involving aversive stimuli and support the contention that dysregulation of GIRK-dependent signaling may underlie cognitive dysfunction in some disorders. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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