| Autor: |
Zhaoling, Zou, Xiangshan, Cao, Zhilin, Wang |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. 27(1) |
| ISSN: |
1003-9406 |
| Popis: |
To investigate the p53 deletion in leukemia patients with complex chromosomal abnormalities (CCA) and the clinical significance.The p53 deletion status of 38 leukemia cases with CCA and 24 cases without CCA were analyzed by interphase fluorescence in situ hybridization (I-FISH).The frequency of p53 deletion in the 38 patients with CCA (44.74%) was significantly higher than that in the 24 cases without CCA (4.16%) (P0.01). The rate of complete remission in 13 cases of acute leukemia with CCA was 15.4%, with median survival time (MST) of 105 days.I-FISH is a rapid, accurate and sensitive technique for detection of p53 deletion, patients with CCA have a higher p53 deletion and a lower complete remission rate and MST. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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