| Autor: |
Matías, Capella, Lucía, Martín Caballero, Boris, Pfander, Sigurd, Braun, Stefan, Jentsch |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Journal of cell science. 133(24) |
| ISSN: |
1477-9137 |
| Popis: |
Misassembled nuclear pore complexes (NPCs) are removed by sealing off the surrounding nuclear envelope (NE), which is conducted by the endosomal sorting complexes required for transport (ESCRT) machinery. Recruitment of ESCRT proteins to the NE is mediated by the interaction between the ESCRT member Chm7 and the inner nuclear membrane protein Heh1, which belongs to the conserved LEM family. Increased ESCRT recruitment results in excessive membrane scission at damage sites but its regulation remains poorly understood. Here, we show that Hub1-mediated alternative splicing of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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