| Autor: |
J L, Pedraz, J M, Lanao, M B, Calvo, C, Muriel, J, Hernández-Arbeiza, A, Domínguez-Gil |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
International journal of clinical pharmacology, therapy, and toxicology. 25(2) |
| ISSN: |
0174-4879 |
| Popis: |
The evolution of the plasma levels of ketamine and its two biotransformation products, norketamine (metabolite I) and dehydronorketamine (metabolite II) was studied after i.v. and epidural administration at doses of 2 and 5 mg/kg, respectively. The results show a good access capacity of ketamine from the epidural space to the systemic circulation as reflected in the high value of its apparent incorporation constant (ka = 5.54 +/- 2.33 h-1) and its good bioavailability (F = 0.77 +/- 0.22). The evaluation of clinical parameters points to a more attenuated cardiovascular and respiratory response after administration of the anesthetic by the epidural route. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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