Interaction Between Orexin-A and Sleep Quality in Females in Extreme Weight Conditions

Autor: Sarah, Sauchelli, Susana, Jiménez-Murcia, Jose C, Fernández-García, Lourdes, Garrido-Sánchez, Francisco J, Tinahones, Felipe F, Casanueva, Rosa M, Baños, Cristina, Botella, Ana B, Crujeiras, Rafael, de la Torre, Jose M, Fernández-Real, Gema, Frühbeck, Roser, Granero, Francisco J, Ortega, Amaia, Rodríguez, Stephan, Zipfel, Katrin E, Giel, Jose M, Menchón, Fernando, Fernández-Aranda
Rok vydání: 2016
Předmět:
Zdroj: European eating disorders review : the journal of the Eating Disorders Association. 24(6)
ISSN: 1099-0968
Popis: The current study examined the relationship between plasma orexin-A and sleep in obesity. Concentrations of orexin-A and sleep were evaluated in 26 obese, 40 morbid obese and 32 healthy-weight participants. The sleep monitor Actiwatch AW7 and the Pittsburgh Sleep Quality Index were used to evaluate sleep. The Symptom Checklist-90-Revised was administered to assess symptoms of psychopathology. A higher weight status was associated with elevated orexin-A levels (p = .050), greater depression, anxiety and somatization symptoms (all: p .001), and impoverished self-reported sleep quality (p .001). A quadratic trend was found in objective sleep time, being longest in the obese group (p = .031). Structural equation modelling showed plasma orexin-A to be related to poor total sleep quality, which in turn was associated with elevated body mass index. Our data confirm an interaction between elevated plasma orexin-A concentrations and poor sleep that contributes to fluctuations in body mass index. Copyright © 2016 John WileySons, Ltd and Eating Disorders Association.
Databáze: OpenAIRE