No association of an insertion/deletion polymorphism in the angiotensin I converting enzyme gene with bipolar or unipolar affective disorders

Autor:	R A, Furlong, M, Keramatipour, L W, Ho, J S, Rubinsztein, A, Michael, C, Walsh, E S, Paykel, D C, Rubinsztein
Rok vydání:	2000
Předmět:	Male Depressive Disorder Bipolar Disorder Polymorphism Genetic Genotype DNA Peptidyl-Dipeptidase A Mutagenesis Insertional Gene Frequency Odds Ratio Humans Female Alleles Sequence Deletion
Zdroj:	American journal of medical genetics. 96(6)
ISSN:	0148-7299 1122-1127
Popis:	A recent Japanese study on the angiotensin I converting enzyme gene (ACE) insertion/deletion polymorphism reported that both the D allele (P0.02) and the DD genotype (P0.002) were significantly more frequent in affective disorder cases than in controls [Arinami et al., 1996: Biol Psychiatry 40:1122-1127]. A replication study was performed by using 157 bipolar I affective disorder cases, 169 major depressive disorder cases, and 313 controls. No significant association with this polymorphism was found in either disorder or in a combined affective disorder group. These results do not support the ACE gene having a major role in the etiology of either bipolar or unipolar affective disorders. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:733-735, 2000.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::91860fd930cc4358c06be41f93233b31 https://pubmed.ncbi.nlm.nih.gov/11121171 Zobrazit plný text záznamu Plný text