Retinoblastoma in transgenic mice: models of hereditary retinoblastoma

Autor:	M D, Mills, J J, Windle, D M, Albert
Rok vydání:	1999
Předmět:	Disease Models Animal Mice Retinal Neoplasms Retinoblastoma Animals Humans Eye Diseases Hereditary Mice Transgenic Genes Retinoblastoma Genes p53 Retinoblastoma Protein
Zdroj:	Survey of ophthalmology. 43(6)
ISSN:	0039-6257
Popis:	Retinoblastoma, the most common intraocular malignancy ill childhood, has served as a paradigm for the study of genetic mechanisms of oncogenesis. The retinoblastoma susceptibility gene RB1 was the first tumor suppressor gene to be cloned, and genetic and molecular biologic studies of this tumor have greatly expanded the understanding of the mechanics of tumorigenesis. Human retinoblastoma has essentially no naturally occuring animal counterpart. The development of transgenic murine models of retinoblastoma have created an experimental tool for manipulation of a tumor gene system in vivo. These models have also enabled studies of new therapeutic modalities. This review outlines the development of the transgenic murine models of retinoblastoma, together with the genetic mechanisms of retinoblastoma origin. Current therapeutic innovations developed by means of the transgenic models are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::917edeae0fcb17c71d6446926bc0621b https://pubmed.ncbi.nlm.nih.gov/10416793 Zobrazit plný text záznamu Full Text from ScienceDirect