Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonist
| Autor: | J M, Cunha, F Q, Cunha, S, Poole, S H, Ferreira |
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| Rok vydání: | 2000 |
| Předmět: |
Lipopolysaccharides
Male Dopamine Sialoglycoproteins Bradykinin Carrageenan Antibodies Dinoprostone Mice Animals Rats Wistar Acetic Acid Pain Measurement Skin Inflammation Sheep Dose-Response Relationship Drug Tumor Necrosis Factor-alpha Immune Sera Interleukin-8 Hindlimb Interleukin-10 Rats Interleukin 1 Receptor Antagonist Protein Hyperalgesia Papers Cytokines Interleukin-4 Interleukin-1 |
| Zdroj: | British journal of pharmacology. 130(6) |
| ISSN: | 0007-1188 |
| Popis: | 1. The effect of IL-1ra on response to intraplantar (i.pl.) injection of LPS, carrageenin, bradykinin, TNFalpha, IL-1beta, IL-8, PGE(2) and dopamine was investigated in a model of mechanical hyperalgesia in rats. 2. IL-1ra inhibited hyperalgesic response to LPS, carrageenin, bradykinin, TNFalpha, and IL-1beta, but not responses to IL-8, PGE(2) and dopamine. 3. A sheep anti-rat IL-1ra serum potentiated response to LPS, carrageenin, bradykinin, TNFalpha and IL-1beta but not IL-8. 4. Carrageenin and LPS stimulated and production of immunoreactive TNFalpha, IL-1beta and IL-1ra in the skin of injected paws. 5. The inhibition by IL-1ra of the hyperalgesic response to carrageenin was not affected by antibodies neutralizing IL-4 and IL-10. 6. In mice, IL-1ra inhibited the nociceptive response to i.p. injection of acetic acid. 7. These data suggest that IL-1ra, released at sites of inflammation, limits inflammatory hyperalgesia. This effect is independent of (IL-1ra-induced) IL-4 and IL-10 and appears to be the result of antagonism by IL-1ra of IL-1beta-stimulated eicosanoid production. |
| Databáze: | OpenAIRE |
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