| Autor: |
Yolanda, Aladro, Rodrigo, Terrero, Marta, Cerezo, Ricardo, Ginestal, Lucía, Ayuso, Virginia, Meca-Lallana, Jorge, Millán, Laura, Borrego, Marisa, Martinez-Ginés, Luisa, Rubio, Clara, de Andrés, Ambrosio, Miralles, Cristina, Guijarro, Elena, Rodríguez-García, José Manuel, García-Dominguez, Carmen, Muñoz-Fernández, Carlos, López de Silanes, Mayra, Gómez, Israel, Thuissard, María, Cerdán, Itziar, Palmí, Luis Felipe, Díaz-Garzón, Jose, Meca-Lallana |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Journal of the neurological sciences. 365 |
| ISSN: |
1878-5883 |
| Popis: |
To estimate the seroprevalence of anti-JCV antibodies, seroconverting rates and evolution of antibody levels in a multiple sclerosis (MS) Spanish cohort.Multicenter, retrospective cross-sectional and longitudinal study. The JCV seroprevalence was analyzed in 711 MS patients by using 1st (STRATIFY-1) and 2nd generation (STRATIFY-2) two-step ELISA over 2.65 (±0.97) years. Seroconversion rate was obtained over 2 samples from 314 patients, and index stability from 301 patients with 3 or more samples available. The effect of each ELISA generation, demographics, clinical characteristics and therapy on seroprevalence was assessed by logistic regression.The overall anti-JCV seroprevalence was 55.3% (51.6-58.9), similar across regions (p=0.073). It increased with age (p0.000) and when STRATIFY-2 was used (60.5%, p=0.001). Neither sex nor immunosuppressive therapy had any influence. Yearly seroconversion rate was 7% (considering only STRATIFY-2). Serological changes were observed in 24/301 patients, 5.7% initially seropositive reverted to seronegative and 7% initially seronegative changed to seropositive and again to seronegative, all these cases had initial index values around the assay's cut-off.JCV seroprevalence in Spanish MS patients was similar to that reported in other European populations. Changes in serostatus are not infrequent and should be considered in clinical decisions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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