Multiple vs. single betamethasone therapy. Neonatal and maternal effects
| Autor: | L, Pratt, L, Waschbusch, W, Ladd, R, Gangnon, S K, Hendricks |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Analysis of Variance Respiratory Distress Syndrome Newborn Anti-Inflammatory Agents Infant Newborn Prenatal Care Betamethasone Medical Records Respiratory Function Tests Obstetric Labor Premature Oxygen Consumption Fetal Organ Maturity Pregnancy Animals Humans Female Lung Retrospective Studies |
| Zdroj: | The Journal of reproductive medicine. 44(3) |
| ISSN: | 0024-7758 |
| Popis: | To identify potential neonatal benefits and possible neonatal and maternal complications associated with repeated use of antenatal corticosteroids.A retrospective chart review was done on all gravidas34 weeks who were hospitalized and received antenatal betamethasone at our institution between January 1, 1992 and April 30, 1996. Regression analysis was performed to investigate the relationship between single vs. multiple course of betamethasone and multiple variables.After controlling for significant covariates, multiple courses of betamethasone were associated with a decrease in oxygen use (P.01). A nonsignificant decline in respiratory distress syndrome and assisted ventilation was noted. No effect on birth weight or maternal or neonatal infection was seen.Repeated use of betamethasone is associated with a significant decrease in oxygen use in the preterm neonate. No significant maternal or neonatal complications were found. A prospective, randomized trial is necessary. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|