Alpha adrenergic receptor blockade increases capillarization and fractional O

Autor: S P, Mortensen, S, Egginton, M, Madsen, J B, Hansen, G D W, Munch, U W, Iepsen, T, Åkerström, B K, Pedersen, Y, Hellsten
Rok vydání: 2016
Předmět:
Zdroj: Acta physiologica (Oxford, England). 221(1)
ISSN: 1748-1716
Popis: To assess the effect of elevated basal shear stress on angiogenesis in humans and the role of enhanced skeletal muscle capillarization on blood flow and OLimb haemodynamics and OResting leg blood flow was increased by 57% 6 h following Terazosin treatment (P0.05), while basal capillary-to-fibre ratio was 1.69 ± 0.08 and increased to 1.90 ± 0.08 after treatment (P0.05). Leg OThese results demonstrate that daily treatment with an α-adrenergic receptor blocker induces capillary growth in human skeletal muscle, likely due to increased shear stress. The increase in capillarization resulted in an increased fractional O
Databáze: OpenAIRE