| Autor: |
M, Toumba, I, Bacopoulou, S C, Savva, N, Skordis |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Indian pediatrics. 44(7) |
| ISSN: |
0019-6061 |
| Popis: |
This study was conducted to study the role of combination therapy of growth hormone and Gonadotropin-releasing hormone (GnRH) analogues in girls with idiopathic central precocious puberty (CPP) or idiopathic short stature (ISS).Five girls with CPP (median age 9.1 y, pubertal stage 2-3) (3 of them previously treated with GnRH analogue (GnRHa) for 16.2 +/- 0.3 months) and 8 girls with ISS (median age 11.4 y, pubertal stage 2-3) (previously treated with GH for 10.95 +/- 1.42 months), were treated with recombinant human GH (0.33 mg/kg/week) and GnRHa (3.75 mg/28 days) for 22 months.Height of girls with CPP improved from - 1.3 to - 0.2 SDS and height for BA from - 2.1 to - 0.6 SDS (P = 0.042). Predicted adult height (PAH) improved from - 3.1 to - 0.6 SDS (P = 0.042). In girls with ISS only PAH improved from - 3.0 to - 1.5 SDS (P = 0.025).Combined treatment improves height and PAH in CPP. Height in ISS is also improved however not significantly. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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