[Acute valproic acid intoxication: interest of a treatment by extracoporeal elimination combined with L-carnitine]

Autor: A, Alluin, J, Jezequel, N, Gauthier, J-L, Desmaretz, C, Canevet
Jazyk: francouzština
Rok vydání: 2009
Předmět:
Zdroj: Annales francaises d'anesthesie et de reanimation. 30(10)
ISSN: 1769-6623
Popis: We present the case of a 24-year-old-female patient, who made an attempt to autolysis with valproic acid, benzodiazepines and neuroleptic. The valproic acid plasma level was very high (1437 μg/mL), confirming it was a severe intoxication. She presents an acute encephalopathy with prolonged status epilepticus, a lactic metabolic acidosis and hematologic disorders such as bicytopenia. Treatment including L-carnintine and continuous veno-venous haemodialysis (CVVHD) was rapidly introduced to prevent the occurrence of cerebral oedema. The evolution was favourable despite the occurrence of a nosocomial ventilation acute lung injury. The patient had motor sequelae of cranial nerves following status epilepticus extended, which disappeared spontaneously after several days.
Databáze: OpenAIRE