| Autor: |
Suzanne M, Verwijnen, Eric P, Krenning, Roelf, Valkema, Jan G M, Huijmans, Marion, de Jong |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 46(12) |
| ISSN: |
0161-5505 |
| Popis: |
During tumor therapy with radiolabeled somatostatin analogs, the kidneys are dose limiting. Renal uptake in patients can effectively be reduced by a 4- to 10-h intravenous infusion of a lysine/arginine solution, thereby increasing the maximum radiation dose to the tumor without renal side effects. Oral administration of amino acids could facilitate this labor-intensive procedure. Therefore, the effects of oral versus intravenous administration of D-lysine were compared in rats injected with [111In-diethylenetriaminepentaacetic acid (DTPA)]octreotide.Rats were intravenously injected with 3 MBq/0.5 microg [111In-DTPA]octreotide and also received D-lysine intravenously or orally in various concentrations and following various time schedules. Twenty-four hours after injection, a biodistribution study and renal ex vivo autoradiography were performed.Renal uptake was reduced significantly-up to 40%-in all lysine-treated groups, without affecting the uptake in other organs.Renal uptake of this radiolabeled peptide can be reduced up to 40% both by oral and by intravenous administration of lysine in rats. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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