| Autor: |
J J, Chomel, N, Simon-Lavoine, D, Thouvenot, M, Valette, J, Choay, L, Chedid, M, Aymard |
| Rok vydání: |
1988 |
| Předmět: |
|
| Zdroj: |
Journal of biological response modifiers. 7(6) |
| ISSN: |
0732-6580 |
| Popis: |
The antiviral activity of a novel biological response modifier (murabutide MDP derivative) has been investigated in 3-week-old OF1 mice infected with influenza (A/Texas/1/77) virus. In each experimental and control group, 10 mice were infected intranasally with a viral dose producing 50% mortality in 5 days and received murabutide via the subcutaneous or intranasal route at various doses either in a simple or in daily repeated administration. All experiments were done in triplicate. Significant prophylactic or therapeutic effects were observed when murabutide was administered the same day as virus, 4 days or 2 days before virus, and 2 days later. These effects varied with the route of administration and the doses of the compound. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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