Evaluation of pregnant rabbits as a laboratory model for bovid herpesvirus-4 infection

Autor: K, Naeem, D D, Caywood, R E, Werdin, S M, Goyal
Rok vydání: 1990
Předmět:
Zdroj: American journal of veterinary research. 51(4)
ISSN: 0002-9645
Popis: A field strain (87-8363) of bovid herpesvirus-4 (BHV-4) isolated from an aborted bovine fetus was used to inoculate pregnant rabbits. Eleven rabbits in midgestation were alloted to 4 groups consisting of 3 infected groups and 1 control group. Rabbits were inoculated with BHV-4 or mock-infected cell culture preparations via IV, intravaginal, and intrauterine routes. Mild vulvovaginitis and endometritis were observed after intravaginal and IV inoculation of BHV-4, whereas intrauterine inoculation of BHV-4 resulted in abortion of hemorrhagic fetuses and nonsuppurative endometritis. Virus was successfully isolated from organ explants of fetal tissues. Rabbits seroconverted 1 week after infection as detected by results of an indirect immunofluorescence assay.
Databáze: OpenAIRE